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Le mécanisme d'action précis du modafinil est mal compris, bien que l'on pense qu'il augmente la phosphorylation de la protéine DARPP-32 dans le noyau accumbens. L'effet secondaire le plus fréquent est la somnolence, bien que ceux qui arrêtent le modafinil puissent ressentir des effets secondaires plus graves tels que l'insomnie. Compte tenu de l'activation des neurones DA dans le noyau tubéromammillaire, il est important de noter que le modafinil inhibe la recapture de la sérotonine dans les neurones sérotoninergiques des noyaux du raphé. Le médicament agit comme un agoniste pour un type de récepteur de la dopamine, le récepteur D4. 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Livrés dans des flacons en verre ambré de 20 ml, les comprimés de Modafinil contiennent 100 mg de médicament. Il peut améliorer le fonctionnement cognitif et l'attention de diverses façons. Le médicament modafinil interagit avec les neurotransmetteurs cérébraux pour fonctionner comme un activateur cognitif. Il a été porté à l'attention pour la première fois en 1992, lorsque le modafinil a été utilisé comme stimulant de l'éveil par un groupe de soldats qui avaient souffert de privation de sommeil en raison d'un régime d'entraînement intensif.

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